What are some database design gotchas to watch out for when you know the database will be accessed using a Object Relational Mapper (ORM) Wikipedia? Also see Entity Framework NHibernate or LLBLGenPro.
As an example, I'll note the 2100 parameter limit on SqlServer's RPC call. This is a problem when using LLBLgen and joining tables when compound primary keys were utilized see MSDN article for compound keys.